Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype
نویسندگان
چکیده
منابع مشابه
Human aortic valve calcification is associated with an osteoblast phenotype.
BACKGROUND Calcific aortic stenosis is the third most common cardiovascular disease in the United States. We hypothesized that the mechanism for aortic valve calcification is similar to skeletal bone formation and that this process is mediated by an osteoblast-like phenotype. METHODS AND RESULTS To test this hypothesis, we examined calcified human aortic valves replaced at surgery (n=22) and ...
متن کاملHuman aortic valve calcification.
To the Editor: Rajamannan et al1 addressed the problem of bone formation in calcified aortic valves, quoting the publication of actual bone formation by Mohler et al.2 Mohler et al had indicated that ossification in calcified aortic valves was relatively common, finding evidence of valve ossification in 36 of 323 patients. Of historical interest, I reported ossification in the left ventricular ...
متن کاملInsulin Resistance in Adipose Tissue but Not in Liver Is Associated with Aortic Valve Calcification
Background. Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results. The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0). Methods. In 1201 subje...
متن کاملBone Morphogenetic Protein Signaling Is Required for Aortic Valve Calcification.
OBJECTIVE Calcific aortic valve disease (CAVD) is the most prevalent type of heart valve disease, affecting ≈2% of the US population. CAVD is characterized by the presence of calcific nodules, resulting in aortic valve (AoV) stenosis; however, the underlying mechanisms driving disease remain unknown. Studies of human diseased AoV provide initial evidence that bone morphogenetic protein (BMP) si...
متن کاملCardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve.
AIMS To determine whether mitral annular calcification and aortic valve calcification, with or without stenosis, are expressions of atherosclerotic disease. METHODS The incidence of atherosclerotic risk factors was analysed in patients with mitral annular calcification and aortic valve calcification and in control patients from a prospective echocardiographic database of 8160 consecutive pati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2003
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000070591.21548.69